Seminar: April 4th The Beacon Automated Single Cell Biology Platform

The Beacon Automated Single Cell Biology Platform

Troy Lionberger, Ph.D., Sr. Manager, Technology Development, Berkeley Lights

Davis Campus:              11 am, Wednesday April 4th;  Room 4202 GBSF/Genome Center Building
Sacramento Campus:    1  pm  , Wednesday April 4th; Room 1241 MedEd building

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The Digital Cell Biology technology developed by Berkeley Lights allows scientists to:

  • Process individual cells radically faster than other technologies
  • Automate and scale workflows far beyond manual, time-intensive analysis
  • Shorten workflows from months to days
  • Reduce a roomful of equipment to a compact platform
  • Quickly change, rearrange and deploy new workflows
  • Apply deep profiling to capture data on cells over time and easily reproduce findings
  • Make important discoveries faster by working with thousands of cells in parallel

The Beacon platform operates cell-labs-on-a-chip for high-throughput workflows. The Beacon platform combines OptoElectroPositioning (OEP) technology, nano-fluidic silicon chips, and high performance fluorescence microscopy into a system in which cells can be viewed, automatically classified and manipulated with high precision in sterile cell culture media. Cells can be automatically selected based on size, shape or fluorescence, positioned into one of 3,500 NanoPen chambers, and cultured. The growth rates and secretion performance can be monitored over time and clones within each pen can then be selectively exported. The miniaturization of cell culture allows unprecedented scale up of experiments, reduction in costs, and great speed up of cell line development projects. The Beacon can be programmed to perform complex workflows such as antibody engineering, gene editing, immuno-oncology studies, cell line robustness screening, memory B-cell Ab discovery, tumor micro-environment studies, and stem cell studies.

 

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